MW
1,024.2 g/mol
Purity
>99%
Pigmentation
MT-2
Melanotan II — Cyclic Alpha-MSH Analog
Cyclic synthetic analog of alpha-melanocyte-stimulating hormone
$75
Per vial · Research use only · COA available
Compound Profile
| Appearance | Lyophilized white powder |
| Molecular Weight | 1,024.2 g/mol |
| Amino Acids | 7 (cyclic) |
| Dosage | 10 mg |
| Volume | 3 mL |
| Solubility | Bacteriostatic or sterile water |
| Purity | ≥98% (HPLC-UV-MS verified) |
| Storage | −20°C long-term · 4°C short-term · Protect from light |
Amino Acid Sequence
Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-NH2
COA, sterility, endotoxin, and heavy metal test results available upon request.
For Research Use Only. This product is not for human consumption, clinical use, or veterinary use. Must be 21+ to purchase. Not evaluated or approved by the FDA for any therapeutic use. Introduction into humans or animals is strictly prohibited by law.
Overview
About MT-2
Melanotan II (MT-2) is a cyclic synthetic analog of alpha-melanocyte-stimulating hormone. Unlike the linear, MC1R-selective MT-1, MT-2's cyclic structure gives it broader, nonselective activity across multiple melanocortin receptor subtypes, making it a research reference compound for both pigmentation pathways and central melanocortin signaling.
Mechanism of Action
How It Works
MT-2 acts as a nonselective agonist across MC1R, MC3R, and MC4R. MC1R activation on melanocytes drives the same cAMP-mediated tyrosinase upregulation and eumelanin synthesis studied with MT-1. Its additional activity at central MC4R receptors has made it a key structural reference in research on appetite regulation and sexual arousal pathways — MT-2's cyclic core is the structural basis from which the more MC4R-selective compound bremelanotide (PT-141) was later derived.
Scientific Literature
Research Highlights
Nonselective melanocortin receptor agonism — MC1R, MC3R, and MC4R activity studied
Pigmentation research via MC1R-mediated tyrosinase and eumelanin pathways
Central MC4R activity — structural precursor referenced in bremelanotide (PT-141) research
Studied appetite-suppression signaling through hypothalamic melanocortin pathways
Studied activity in sexual arousal and libido research models via central MC4R
Broader receptor profile used as a comparative reference against selective analogs like MT-1
Cyclic peptide structure studied for receptor-binding stability
Research Disclaimer: All research highlights are derived from published preclinical, in vitro, and animal studies. Results observed in laboratory models may not translate to human outcomes. Genfinite makes no claims regarding therapeutic efficacy. All products are sold strictly for scientific research purposes only.
Handling
Storage & Reconstitution
Dry Storage
Store lyophilized powder at −20°C, away from light and moisture. Do not open until ready to use. Shelf life is significantly extended by proper dry storage.
Reconstitution
Reconstitute using Bacteriostatic or sterile water. Add solvent slowly to the side of the vial and allow to dissolve gently. Do not shake vigorously.
Post-Reconstitution
Store reconstituted solution refrigerated at 4°C. Use within your laboratory's established timeframe. Do not refreeze after reconstitution.
